aminophylline 100 mg tablets dosage citalopram

In addition, certain concurrent illnesses and alterations in normal physiology (see Table I) and co-administration of other drugs (see Table II) can significantly alter the pharmacokinetic characteristics of theophylline.

Some conditions may become worse when this drug is suddenly stopped.

Theophylline: The effect of steady-state Fluvoxamine (50 mg b.i.d.) Take this medication regularly to get the most benefit from it. Diseases & Conditions encoded search term (citalopram (Celexa)) and citalopram (Celexa) New Data on Birth Defects With Antidepressant Use in PregnancyHallucinations May Point to Rare, Non-Psychotic ConditionTooth Wear in Patients Treated With HIV Anti-retroviral TherapyFive Healthy Lifestyle Choices Tied to Dramatic Cut in Dementia RiskNew Data on Birth Defects With Antidepressant Use in PregnancySupplement Plus Probiotic May Improve Depressive Symptoms COVID-19 Tied to Wide Range of Neuropsychiatric ComplicationsShare cases and questions with Physicians on Medscape consult. Adding a drug that inhibits theophylline metabolism (e.g., cimetidine, erythromycin, tacrine) or stopping a concurrently administered drug that enhances theophylline metabolism (e.g., carbamazepine, rifampin). Do not store in the bathroom. Diseases & Conditions Do not increase your dose or use this drug more often or for longer than prescribed. Charcoal hemoperfusion is the most effective method of extracorporeal removal, increasing theophylline clearance up to six fold, but serious complications, including hypotension, hypocalcemia, platelet consumption and bleeding diatheses may occur. The amount of medicine that you take depends on the strength of the medicine.

Different rates of elimination and consequent dosage requirements have been observed among other peoples. Co-administration of theophylline with food or antacids does not cause clinically significant changes in the absorption of theophylline from immediate-release dosage forms.Once theophylline enters the systemic circulation, about 40% is bound to plasma protein, primarily albumin.

Specifically, the serum theophylline concentration should be measured as follows:To guide a dose increase, the blood sample should be obtained at the time of the expected peak serum theophylline concentration; 1-2 hours after a dose at steady-state. Not to exceed 40 mg/day because of increased risk for QT prolongation. Do not use a household spoon because you may not get the correct dose.To reduce your risk of side effects, your doctor may direct you to start taking this drug at a low dose and gradually increase your dose. Depression in patients whose diagnosis corresponds most closely to the DSM-III and DSM-III-R category of major depressive disorderIf needed, may increase to 40 mg/day after at least 1 weekDoses above 40 mg/day are not recommended, because of risk for QT prolongation without additional benefit for treating depressionPoor CYP2C19 metabolizers or coadministration with CYP2C19 inhibitors (eg, cimetidine, fluconazole, omeprazole): Do not exceed 20 mg/dayHepatic impairment decreases clearance and therefore increases risk of QT prolongation; do not exceed 20 mg/day20 mg PO qDay initially; after 1 week, may increase to 40 mg/day if warrantedNot to exceed 40 mg/day because of increased risk for QT prolongationInitial: 10 mg PO qDay; may increase to 20 mg/day after 1 weekInitial: 20 mg PO qDay; may titrate to 40-60 mg/day; improvement may be seen 4-6 weeks after initiating therapy5 mg PO on the estimated day of ovulation; increase dose by 5 mg each day thereafter to maximum 30 mg; continue thereafter until menstruation begins; decrease dose to 20 mg on the first day of menstruation; the next day, decrease to 10 mg; stop the treatment from day 3 until ovulation begins10 mg PO qDay; titrate by 10 mg/week, as tolerated to maximum 40 mg/day-The elderly are more prone to SSRI/SNRI-induced hyponatremia and risk for QT prolongationIn short-term studies, antidepressants increased the risk of suicidal thinking and behavior in children, adolescents, and young adults (<24 years) taking antidepressants for major depressive disorders and other psychiatric illnessesThis increase was not seen in patients >24 years; a slight decrease in suicidal thinking was seen in adults >65 yearsIn children and young adults, the risks must be weighed against the benefits of taking antidepressantsPatients should be monitored closely for changes in behavior, clinical worsening, and suicidal tendencies; this should be done during initial 1-2 months of therapy and dosage adjustmentsThe patient’s family should communicate any abrupt changes in behavior to the health-care providerWorsening behavior and suicidal tendencies that are not part of the presenting symptoms may require discontinuation of therapyNot FDA approved for the treatment of bipolar disorderThis drug is not FDA approved for use in pediatric patientsPregnancy: Conflicting evidence regarding use of SSRIs during pregnancy and increased risk of persistent pulmonary hypertension of the newborn, or PPHN (see Pregnancy)Neonates exposed to SNRIs/SSRIs late in third trimester: Risk of complications such as feeding difficulties, irritability, and respiratory problemsClinical worsening and suicide ideation may occur despite medication in adolescents and young adults (18-24 years)Risk of mydriasis; may trigger angle closure attack in patients with angle closure glaucoma with anatomically narrow angles without a patent iridectomyRisk of hyponatremia, abnormal bleeding (increased if concomitant aspirin, NSAIDs, or anticoagulants, or hemorrhagic diathesis), and impairment of cognitive and motor functionsRisk of serotonin syndrome or neuroleptic malignant syndrome (NMS)-like reactions have been reported with SSRIs alone or with concomitant use of serotonergic drugs, with drugs that impair metabolism of serotonin, or with antipsychotics or other dopamine antagonistsActivation of mania/hypomania has been reported; use caution when treating patients with history of maniaIncreased risk of bone fractures reported with antidepressant use; use caution; consider possibility of fracture it patient presents with bone painUse caution when treating patients with history of seizure disorderRare cases of hyponatremia and development of SIADH reported with either SSRI or SNRI useConsider risk of serotonin syndrome if administered concomitantly with other serotonergic drugs including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, amphetamines, and St. John’s WortNot recommended in patients with uncompensated heart failureUse late in the third trimester associated with complications in newborns and may require prolonged hospitalization, respiratory support, and tube feedingA: Generally acceptable.